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Charge
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Hence, the pH of the
drug reservoir, which affects drug ionization, will influence the efficacy of
drug delivery. The transport of neutral molecules is also enhanced by electroporation,
due to passive diffusion through the permeabilized skin [37]. (lit 1) – page
665)
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Molecular weight
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The greater the molecular
size, the lower the transdermal transport. The absence of molecular weight
cut off (at least up to 40 kDa) suggested that electroporation could be
useful for macromolecule delivery. (lit 1) page 665).
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Concentration
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The higher the drug
concentration, the higher the transport. However, a non-linear relationship
between the quantity of drug delivered in
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the skin and the
drug concentration of the reservoir has been reported [29,47]. (lit 1) page
665).
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电流参数
